Ancient origin of RNA editing in kinetoplastid protozoa.
نویسندگان
چکیده
A rooted phylogenetic tree of the kinetoplastid protozoa has been constructed that, together with a comparative analysis of editing of several genes, leads to the surprising conclusion that extensive or pan-editing with multiple overlapping guide RNAs is more ancient than 5'-editing. The mechanism of editing is still uncertain, but multiple ribonucleoprotein complexes have been identified that contain components of the enzymatic machinery.
منابع مشابه
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عنوان ژورنال:
- Current opinion in genetics & development
دوره 4 6 شماره
صفحات -
تاریخ انتشار 1994